A blood test of “NfL” proteins answers questions about damage severity that doctors—and families—desperately need.
NEIL GRAHAM SEES a lot of head injuries: “Car accidents, violence, assault, gunshots, stabbing—the works, really,” says Graham, a neurologist from Imperial College London who practices at St. Mary’s Hospital nearby.
Doctors stop the bleeding, they relieve any pressure building inside the skull, maybe they’ll put the patient into a coma to keep the brain from overworking when it needs to relax and heal. Imaging can also help—to an extent. CT scans or MRIs pinpoint bruising or specks of hemorrhage in gray matter, the brain’s outer layer where neurons do most of their processing. But a clean scan isn’t a clean bill of health. Trauma to axons—a neuron’s root-like fibers that extend toward other neurons—often appears only in the deeper white matter, sometimes eluding simple scans.
The latest in “electronic medicine” offers an alternative to temporary pacemakers and could help reduce tissue scarring.
THE HEART—THAT PARAGON of natural rhythm—sometimes needs help to stay on beat. Permanent pacemakers, which supply jolts of muscle-contracting current to regulate each thump, can correct chronically irregular hearts, and temporary ones can resolve fleeting dysfunctions that follow open heart surgery. Doctors wire up the heart with electrical leads that pass through the skin, and the muscle tissue envelopes the intruding electrodes like quicksand.
But if the pacemaker is just a temporary precaution, it’s all got to come out. And that’s where it gets tricky.
The fiber has been considered a “miracle material” for anything from body parts to food. Has the revolution finally arrived?
ALI ALWATTARI STILL remembers the day he met the goats. It was mid-May, 19 years ago, in Quebec. The sun was lighting up the old maple sugar farm—and small huts where the goats were living. Alwattari, a materials scientist, had spent his career tinkering with chemistry equipment for Procter & Gamble, developing fibers used in Pampers and Swiffers. But the startup Nexia Biotechnologies was aiming to use an entirely different kind of polymer producer—and it was gazing back at him with its rectangular pupils.
The device may make it easier to quickly test newborns and could open the door to at-home monitoring.
IN THE MIDDLE Ages, a grim adage sometimes turned up in European folklore and children’s stories: Woe to that child which when kissed on the forehead tastes salty. He is bewitched and soon must die. A salty-headed newborn was a frightful sign of a mysterious illness. The witchcraft diagnosis didn’t hold, of course, but today researchers think that the salty taste warned of the genetic disease we now know as cystic fibrosis.
Take a minute to think about what you’re wearing right now. Not the colors or cuts of fabric you grabbed out of your closet this morning—but the textiles your clothes are made of.
Before your clothes became clothes, they were raw resources that were collected, processed, woven into textiles, then cut and sewn into the garments on your back. And their life cycle doesn’t end there. Nearly 90% of clothing takes an inevitable trip from closet to landfill. The problem is that although this process provides short-term convenience for customers and the fashion industry, in the long run, it’s not sustainable. Making and transporting clothes consumes raw materials and, at every step in the process, emits greenhouse gases.
Ask Brandon Presley about any twist and turn in his chemistry journey, and he’ll tell you about people: The high school teacher who gave him the courage to sink his teeth into chemistry; the family and friends who encouraged him; and the mentors and colleagues who gave him focus when he’d spread himself too thin. For Presley, that deep connection between chemistry and people motivates him every day.
One day a “magic carpet” based on this light-induced flow technology could carry climate sensors high in the atmosphere—wind permitting.
IN THE BASEMENT of a University of Pennsylvania engineering building, Mohsen Azadi and his labmates huddled around a set of blinding LEDs set beneath an acrylic vacuum chamber. They stared at the lights, their cameras, and what they hoped would soon be some action from the two tiny plastic plates sitting inside the enclosure. “We didn’t know what we were expecting to see,” says Azadi, a mechanical engineering PhD candidate. “But we hoped to see something.”
Let’s put it this way: They wanted to see if those plates would levitate, lofted solely by the power of light.
Yajaira Sierra-Sastre is always looking for new worlds to explore. As a young girl growing up in Puerto Rico, she gazed at stars through a clear night sky. “My first passion was for anything related to astronomy and planets and stars and space,” she says. Sierra-Sastre fell in love with science during childhood, and went on to study chemistry at the University of Puerto Rico, Mayagüez.“I could see chemistry all around me,” Sierra-Sastre says. After graduating, she started on a path to connect her studies with the real world in as many new ways as possible. “I had this desire of just going out on an adventure.”
In the 20 years since, she has used her degree to teach high school chemistry; earn a PhD making nanomaterials for space experiments; help create new types of textiles and batteries; spend months living in a Mars simulation; and oversee the research projects that keep printed money secure.
This glowing microneedle test could catalyze a transition from blood-based diagnostics to a stick-on patch.
A RIVER OF biological information flows just beneath the outermost layers of your skin, in which a hodgepodge of proteins squeeze past each other through the interstitial fluid surrounding your cells. This “interstitium” is an expansive and structured space, making it, to some, a newfound “organ.” But its wealth of biomarkers for conditions like tuberculosis, heart attacks, and cancer has attracted growing attention from researchers looking to upend reliance on diagnostic tools they say are inefficient, invasive, and blood-centric.